ABSTRACT
Multiparametric indices offer a more comprehensive approach to voice quality assessment by taking into account multiple acoustic parameters. Artificial intelligence technology can be utilized in healthcare to evaluate data and optimize decision-making processes. Mobile devices provide new opportunities for remote speech monitoring, allowing the use of basic mobile devices as screening tools for the early identification and treatment of voice disorders. However, it is necessary to demonstrate equivalence between mobile device signals and gold standard microphone preamplifiers. Despite the increased use and availability of technology, there is still a lack of understanding of the impact of physiological, speech/language, and cultural factors on voice assessment. Challenges to research include accounting for organic speech-related covariables, such as differences in conversing voice sound pressure level (SPL) and fundamental frequency (f0), recognizing the link between sensory and experimental acoustic outcomes, and obtaining a large dataset to understand regular variation between and within voice-disordered individuals. Our study investigated the use of cellphones to estimate the Acoustic Voice Quality Index (AVQI) in a typical clinical setting using a Pareto-optimized approach in the signal processing path. We found that there was a strong correlation between AVQI results obtained from different smartphones and a studio microphone, with no significant differences in mean AVQI scores between different smartphones. The diagnostic accuracy of different smartphones was comparable to that of a professional microphone, with optimal AVQI cut-off values that can effectively distinguish between normal and pathological voice for each smartphone used in the study. All devices met the proposed 0.8 AUC threshold and demonstrated an acceptable Youden index value.
ABSTRACT
Sexual dysfunction (SD) is frequently encountered in patients suffering from depression. There is a bidirectional relationship between various types of SD and depression, so the presence or treatment of one condition may exacerbate or improve the other condition. The most frequent sexual problem in untreated depressed patients is declining sexual desire, while in treated depressed patients it is difficulties with erection/ejaculation and with orgasm. Numerous classes of neuropsychiatric medications, commonly used in depressed patients—such as antidepressant, antipsychotic, alpha sympathetic, and opioid drugs—may cause SD. Photobiomodulation (PBM) therapy, also called low-level light/laser therapy, is a novel neuromodulation technique for neuropsychiatric conditions, such as depression. Transcranial PBM (tPBM) targets the cellular metabolism—through the mitochondrial respiratory enzyme, cytochrome c oxidase—and has numerous cellular and physiological beneficial effects on the central nervous system. This paper represents a comprehensive review of the application of tPBM to SD, coexisting with depression or induced by antidepressant medications.
ABSTRACT
Exposure to small public urban green spaces (SPUGS) has been demonstrated to have mental benefits for older adults. However, studies on identifying the objective environmental features of SPUGS and their effects on mental restoration for older adults remain limited. This study employed a multilevel regression model to investigate the restorative and vitalizing effects of the environmental features of 11 SPUGS in Tokyo. Onsite measurements were conducted in Kita-Ku, and 202 older adults were surveyed. The results showed that: (1) The fitting curve of the green view index and Restoration Outcome Scale (ROS) score showed an inverted U shape—both green view index and boundary enclosure had a strong impact on the mental restoration of older adults;(2) The colorfulness index showed the strongest relationship with the vitalizing effect. (3) The sky view factor and number of seats only influenced the ROS score, while the results of revitalization suggest that large areas of water should be avoided. (4) Physiological Equivalent Temperature (PET) was also confirmed to have negative effects on the mental restoration of older adults in autumn. These empirical findings can be used as a resource to promote the mental health of older adults in the design of SPUGS in high-density Asian countries.
ABSTRACT
Aeromedical evacuation is associated with several stressors that may cause harm during casualties' transport. In addition to these stressors, timing, oxygen supplementation and altitude may have additional effects that are currently unknown. The purposes of this proposal are to better evaluate the effect of these additional variables and define an adequate timing, oxygen supplementation level and best appropriate altitude to maintain normal organ physiology. This proposal includes the use of two different animal models, rats and swine, using different and complement strategies to better understand the effects of aeromedical evacuation. So far, our results showed the feasibility of our models to monitor the effects of aeromedical evacuation on neurobehavioral damage, inflammatory response and hemodynamic changes. Specifically, we showed no changes in behavioral or pathological changes in the short term of transport after injury in the rat model but noticed modification in the inflammatory response. In addition, we established a swine model that can be used to monitor hemodynamic changes during aeromedical evacuation with different levels of oxygen and altitude.
ABSTRACT
This article deals with the treatment and application of cardiac biosignals, an excited accelerometer, and a gyroscope in the prevention of accidents on the road. Previously conducted studies say that the seismocardiogram is a measure of cardiac microvibration signals that allows for detecting rhythms, heart valve opening and closing disorders, and monitoring of patients’ breathing. This article refers to the seismocardiogram hypothesis that the measurements of a seismocardiogram could be used to identify drivers’ heart problems before they reach a critical condition and safely stop the vehicle by informing the relevant departments in a nonclinical manner. The proposed system works without an electrocardiogram, which helps to detect heart rhythms more easily. The estimation of the heart rate (HR) is calculated through automatically detected aortic valve opening (AO) peaks. The system is composed of two micro-electromechanical systems (MEMSs) to evaluate physiological parameters and eliminate the effects of external interference on the entire system. The few digital filtering methods are discussed and benchmarked to increase seismocardiogram efficiency. As a result, the fourth adaptive filter obtains the estimated HR = 65 beats per min (bmp) in a still noisy signal (SNR = −11.32 dB). In contrast with the low processing benefit (3.39 dB), 27 AO peaks were detected with a 917.56-ms peak interval mean over 1.11 s, and the calculated root mean square error (RMSE) was 0.1942 m/s2 when the adaptive filter order is 50 and the adaptation step is equal to 0.933.
ABSTRACT
The current study is attempting to derive the reference to the hierarchy of Maslow, where the consumers were placed before the arrival of Covid-19 and during the lockdown time. Consumer behavior consists of cognitive, emotional or physical activities in which people pick, purchase, consume and dispose of products and services to satisfy their choices and expectations. Abraham Maslow defined hierarchy of needs in different forms viz Physiological, Safety,Social,Esteem and Self-actualization needs. A multiplicity of competing factors influences human behaviour and thereby needs and requirements. Recognition of needs is essential as the initial step for market participants in the supply chain. At the same time recognising where the needs of consumers will alter is parallelly significant for smooth functioning of market processes and securing profitability along with capturing the trend. In the present study with the help of primary survey need recognition or any sort of variation therein, pre and during the Covid-19 lockdown periodare traced within the conceptual framework of Maslow Hierarchy of needs theory.
ABSTRACT
BACKGROUND: International COVID-19 guidelines recommend that health care workers (HCWs) wear filtering facepiece (FFP) respirators to reduce exposure risk. However, there are concerns about FFP respirators causing hypercapnia via rebreathing carbon dioxide (CO2). Most previous studies measured the physiological effects of FFP respirators on treadmills or while resting, and such measurements may not reflect the physiological changes of HCWs working in the emergency department (ED). OBJECTIVE: Our aim was to evaluate the physiological and clinical impacts of FFP type II (FFP2) respirators on HCWs during 2 h of their day shift in the ED. METHODS: We included emergency HCWs in this prospective cohort study. We measured end-tidal CO2 (ETCO2), mean arterial pressure (MAP), respiratory rate (RR), and heart rate values and dyspnea scores of subjects at two time points. The first measurements were carried out with medical masks while resting. Subjects then began their day shift in the ED with medical mask plus FFP2 respirator. We called subjects after 2 h for the second measurement. RESULTS: The median age of 153 healthy volunteers was 24.0 years (interquartile range 24.0-25.0 years). Subjects' MAP, RR, and ETCO2 values and dyspnea scores were significantly higher after 2 h. Median ETCO2 values increased from 36.4 to 38.8 mm Hg. None of the subjects had hypercapnia symptoms, hypoxia, or other adverse effects. CONCLUSION: We did not observe any clinical reflection of these changes in physiological values. Thus, we evaluated these changes to be clinically insignificant. We found that it is safe for healthy HCWs to wear medical masks plus FFP2 respirators during a 2-h working shift in the ED.
Subject(s)
COVID-19 , Occupational Exposure , Adult , COVID-19/prevention & control , Carbon Dioxide , Dyspnea/etiology , Dyspnea/prevention & control , Emergency Service, Hospital , Health Personnel , Humans , Hypercapnia , Masks , Occupational Exposure/adverse effects , Occupational Exposure/prevention & control , Prospective Studies , Ventilators, Mechanical , Young AdultABSTRACT
Effects of drought and aerosol stresses were studied in a factorial experiment based on a Randomized Complete Design with triplicates on two ornamental shrubs. Treatments consisted of four levels of water container (40%, 30%, 20%, and 10% of water volumetric content of the substrate) and, after 30 days from experiment onset, three aerosol treatments (distilled water and 50% and 100% salt sea water concentrations). The trial was contextually replicated on two species: Callistemon citrinus (Curtis) Skeels and Viburnum tinus L. ‘Lucidum’. In both species, increasing drought stress negatively affected dry biomass, leaf area, net photosynthesis, chlorophyll a fluorescence, and relative water content. The added saline aerosol stress induced a further physiological water deficit in plants of both species, with more emphasis on Callistemon. The interaction between the two stress conditions was found to be additive for almost all the physiological parameters, resulting in enhanced damage on plants under stress combination. Total biomass, for effect of combined stresses, ranged from 120.1 to 86.4 g plant−1 in Callistemon and from 122.3 to 94.6 g plant−1 in Viburnum. The net photosynthesis in Callistemon declined by the 70% after 30 days in WC 10% and by the 45% and 53% in WC 20% and WC 10% respectively after 60 days. In Viburnum plants, since the first measurement (7 days), a decrease of net photosynthesis was observed for the more stressed treatments (WC 20% and WC 10%), by 57%. The overall data suggested that Viburnum was more tolerant compared the Callistemon under the experimental conditions studied.
ABSTRACT
Urban parks are important urban public spaces that guarantee people recreation, create positive emotions and relieve stress. Emerging research has shown that natural soundscapes are associated with restorative landscapes in urban parks. However, there is still a lack of knowledge on the use of physiological indexes to evaluate the effects of natural sounds versus human-based sounds on stress relief. In this study, the three physiological indexes of skin conductance level, heart rate and heart rate variability were collected in Fuzhou West Lake Park with the help of Ergo LAB data platform, and a soundscape perception evaluation questionnaire was used to assess the degree of soundscape perceptions in the sample sites. The differences in the stress relieving effects of different urban park environments were analysed by applying the median test, the Wilcoxon test was applied to analyse the effects of soundscapes and urban park environments on relieving stress, and regression analysis was used to identify the important factors of restorative soundscapes. The results found that urban park environments provide a certain degree of stress relief, but the stress relieving effects of different urban park environments vary and that natural spaces play an important role in relieving stress. Urban park soundscapes are key to restorative environmental design, with natural sounds such as birdsong and stream sound being important factors of restorative soundscapes.
ABSTRACT
Melatonin is registered to treat circadian rhythm sleep-wake disorders and insomnia in patients aged 55 years and over. The essential role of the circadian sleep rhythm in the deterioration of sleep quality during COVID-19 confinement and the lack of an adverse effect of melatonin on respiratory drive indicate that melatonin has the potential to be a recommended treatment for sleep disturbances related to COVID-19. This review article describes the effects of melatonin additional to its sleep-related effects, which make this drug an attractive therapeutic option for treating patients with COVID-19. The preclinical data suggest that melatonin may inhibit COVID-19 progression. It may lower the risk of the entrance of the SARS-CoV-2 virus into cells, reduce uncontrolled hyper-inflammation and the activation of immune cells, limit the damage of tissues and multiorgan failure due to the action of free radicals, and reduce ventilator-induced lung injury and the risk of disability resulting from fibrotic changes within the lungs. Melatonin may also increase the efficacy of COVID-19 vaccination. The high safety profile of melatonin and its potential anti-SARS-CoV-2 effects make this molecule a preferable drug for treating sleep disturbances in COVID-19 patients. However, randomized clinical trials are needed to verify the clinical usefulness of melatonin in the treatment of COVID-19.